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We Can Help You at Every Stage

We know crops, from cereals and vegetables to top fruit and vines.

Plant & Animal Metabolism

Get your agrochemical and agricultural pharmaceutical or nutritional products to market safely and reliably with Battelle’s comprehensive plant and animal metabolism studies. We combine industry-leading expertise to deliver fast, reliable metabolism, pharmacokinetic (PK) and toxicokinetic (TK) studies for product registration and regulatory support.


Our studies will determine the nature of your products’ residues and metabolic pathways in plants and animals as well as assess the potential for their accumulation and metabolism in soil residue – providing the reliable data you need to make product development decisions.

Looking for integrated metabolism services for fast, reliable answers?
Contact us today to learn more.
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We can help you at every stage of the process, from needs assessment and study design to execution and dossier development. We can perform single studies for product registration and complex, customized projects to meet your unique requirements. Our study directors take a proactive approach to ensure excellent communication is maintained with the client and principal investigators where applicable. 

We have extensive in vitro and in vivo experience and can accurately isolate, identify and characterize known and unknown metabolites in tissues and excreta. Our plant metabolism studies can be conducted in the greenhouse under environmentally controlled conditions or outside where typical farming and climatic conditions can be more closely simulated. We use state-of-the-art equipment and analytical techniques to give you accurate, dependable data. We perform studies on a full range of crops including cereals, vegetables, top fruit and vines. We are fully compliant with Good Laboratory Practices (GLP) and experienced in handling highly toxic, radiolabeled and biohazard samples.


Our services include: 

In Vivo PK and TK Studies
As part of our general toxicology services, we perform in vivo pharmacokinetic and toxicokinetic studies in large and small models. Our small model studies use Empis/Culex/Raturn technology for automated dosing and sample collection.  

In Vitro Metabolism
Battelle has extensive experience in evaluating in vitro metabolism with CYPs (cytochrome P450s), liver microsomes and hepatocytes. We identify major CYPs responsible for metabolism of candidates, examine the interaction potential for CYP inhibition and induction, and characterize metabolic pathways.

Our multidisciplinary teams combine bioanalytical and kinetic services for integrated, efficient kinetic studies. Our kineticists are experienced with a variety of exposure methods (intravenous, intraperitoneal, intramuscular, intrathecal, oral, dermal, dosed-feed, dosed-water and inhalation) and numerous species, including rat, hen, goat and swine.

Veterinary Health and Nutrition
Battelle can help you get new medicines and nutritional products for livestock and companion animals to market safely and efficiently.  We provide a full range of toxicology services for agri-pharmacological and nutritional product registration.

Other Areas of Expertise
Our in-house support services include genomics, proteomics, bioinformatics, biomarkers and more to advance your product development goals. We also conduct bioavailability and bioequivalence studies, compartmental modeling, noncompartmental analysis, and pharmacokinetic/ pharmacodynamic analysis.  


Move your products to market quickly and confidently with reliable, defensible data and regulatory support.

Measuring Agrichemical Residue Levels in Fish Populations


The European Union recently passed new registration requirements for all agrichemical products. Under the new rules, agrichemical companies are now required to evaluate exposure and accumulation in fish in addition to livestock. They now must be able to demonstrate that the bioaccumulation in fish under expected usage scenarios do not threaten fish population levels or present human health risks if the fish are ingested. In order to meet the new requirements, agrichemical manufacturers needed a new kind of study designed to assess how chemicals are metabolized by fish and how they accumulate in living tissue.


Fish can be exposed to agrichemicals in two primary ways: through residues present in crops that are incorporated into fish food, and through exposure to water that is contaminated with agricultural runoff. Typical bioaccumulation studies with livestock involve exposing animals to controlled doses of the chemical through feed or drinking water. However, fish populations present special challenges. Battelle partnered with [NAME] to develop new types of studies in order to help companies meet the new registration requirements.

For each chemical to be evaluated, we first look at how and where the chemical is used and the most likely routes of exposure for fish populations. Then we design a custom study in order to evaluate how the chemical is metabolized and how it accumulates in tissues. In feeding studies, we apply controlled doses of the chemical in fish food and measure the eventual tissue accumulation. Accumulation levels can then be checked against Acceptable Daily Intake guidelines to determine if the levels present a risk to human health if the fish is ingested at normal consumption levels. In metabolism studies, we evaluate how the chemical is broken down or excreted by fish.


Our fish metabolism and bioaccumulation studies are helping agrichemical companies meet the new EU requirements for reregistration or new product registration. By combining both bioaccumulation and metabolism studies together, we can save time and money for agrichemical companies and provide all of the information they need for product registration in one well-designed study. As EU, U.S. and global registration requirements change, our study designs will continue to evolve to help companies meet the new requirements safely and cost-effectively.

Office Locations

505 King Avenue
Columbus, OH 43201
Phone: 800-201-2011
or 614-424-6424


141 Longwater Drive, Suite 202
Norwell, MA 02061


Battelle UK Limited
29, Springfield Lyons Approach
Chelmsford Business Park
Springfield, Chelmsford
Essex, CM2 5LB, UK


Battelle UK Limited
Langstone Technology Park
Langstone Road