arrows arrow-right arrow-left menu search rss youtube linkedin twitter instagram facebook arrow-play

Featured Offerings

Medical Devices
Drug Delivery

When you are looking to select or develop the optimal delivery mechanism for a new drug or therapy and accelerate their path through the regulatory process, think Battelle.

Learn More about Drug Delivery
Preclinical Research
IND-enabling Toxicology & Pharmacology

Whether you’re trying to get a new vaccine or therapeutic to market or quantify the exposure risks of an industrial or agricultural chemical, you can count on the Battelle for the answers you need.

Learn More about IND-enabling Toxicology & Pharmacology
Medical Devices

Battelle works daily at the intersection of science and technology and is pioneering ways to help people overcome devastating neurological damage and disorders.

Learn More about Neurotechnology

Featured Products and Services by Battelle

Environmental Restoration
PFAS Assessment

From the field to the lab, Battelle is leading the way in development of new solutions for emerging environmental problems—like per- and polyfluoroalkyl substances (PFAS).

Learn More about PFAS Assessment
NeuroLife® Technology

For a person with a nervous system injury, everyday tasks can be overwhelming – if not impossible. Battelle’s technology aims to help patients overcome these hurdles.

Learn More about NeuroLife® Technology
High Hazard & Biocontainment Toxicology
Emerging Infectious Diseases

Battelle offers valuable analysis and assessment for vaccines, prophylactic compounds and therapeutics for a wide array of infectious diseases, medical countermeasures and biological threats.

Learn More about Emerging Infectious Diseases

VIDEO: PFAS Annihilator™ Destruction Technology

Featured Videos

Latest News

Inside Battelle Blog

View Blog Post by Category

3 Innovations Improving Safety Pharmacology Testing

Sep 11, 2017, 10:13 AM
Toxicology safety testing teams are under more pressure than ever. Here are three significant innovations helping tox teams achieve more success.
Title : 3 Innovations Improving Safety Pharmacology Testing
Post author : Battelle Insider
Related YouTube link :
Display category : Toxicology
Featured Post : No
Allow Comments : No

Toxicology safety testing teams are under more pressure than ever from increased regulation, tight budgets and increasingly aggressive timelines. In response, forward-thinking toxicologists are deploying innovative methods to get more out of their testing strategies while staying profitable. 

Here are three significant innovations helping tox teams achieve more success. 

Simultaneous Testing of Multiple Endpoints with a Single Model 

Traditionally, cardiovascular (CV), central nervous system (CNS) and pulmonary tests are performed separately, with different test subjects, to ensure that testing activities for one type of study do not confound the results of the others. However, in many cases it is possible to design testing protocols that assess two — or even all three — of these safety pharmacology endpoints (CV, CNS and pulmonary) simultaneously in the same animal.

Simultaneous testing can help tox leaders: 

  • Reduce study costs and timelines
  • Gain better insights into body system interactions
  • Create less stress for the testing model
  • Reduce number of animals required for testing

Find test method details by downloading our Three Innovations Improving Safety Pharmacology Testing white paper. 

Automated Dosing and Collection to Improve Data Accuracy

As scientists, we take multiple precautions to mitigate the effects of interaction and handling that can confound data. However, manual or chemical restraint can make it difficult to interpret data and draw accurate conclusions. 

Now scientists can minimize animal stress and increase data accuracy by 1) using automated, intravenous dosing and blood collection systems and 2) employing wireless telemetry and pre-study subject acclimation procedures.

These approaches help:

  • Improve data accuracy by reducing stress of human interaction
  • Increase collection efficiency with a seamless transition between pre-dose and post-dose data collection
  • Offer more realistic physiological data by reducing stress in testing subject

Find test method details by downloading the Three Innovations Improving Safety Pharmacology Testing white paper. 

Utilizing Better Models to More Reliably Predict Effects in Humans

Predictions based on typical animal models can be misleading due to differences in human and animal physiology. 

Four new models — now in development — can provide better predictive value for human physiological responses. These models include: using peripheral pressure measurements in CV studies, introducing NHP models for pulmonary hypertension, measuring pulmonary pressure continuously, and combining pharmacokinetic and pharmicodynamic studies.  

Utilizing better models can help safety pharm professionals:

  • Increase accuracy of predictions about safety and efficacy of hypertension drugs
  • Improve understanding of chronic drug exposure by decreasing inter-animal variability
  • Make earlier, more informed decisions about drug development by measuring physiologic parameters simultaneously

Find test model details by downloading the Three Innovations Improving Safety Pharmacology Testing white paper. 

Does Your Safety Pharm Team Need to Innovate?

In an industry that is predominantly conservative and highly regulated, innovation is needed to get new products to market safely and efficiently. Download the Three Innovations Improving Safety Pharmacology Testing white paper for details about research methods that may help you find better, faster and more reliable ways to get the data that you need. 

Categories :
  • Defense
  • Health
Tags :
  • IND-enabling Toxicology & Pharmacology
  • safety pharmacology
Related Markets :
Related Market Segments :
Related Solutions :
Related Expertise :
Related Sub Expertise :
girl laying in hospital bed holding a teddy bear
Related battelle banners
Related battelle banners
Related pages : Health