ThreatSEQ™ DNA Screening Web Service
Faster, Better Decisions for the Gene Synthesis Industry
ThreatSEQ DNA screening web service offers gene synthesis companies a faster alternative to manual and subjective DNA screening options. Now, these institutions are empowered to make better decisions for protecting themselves, their customers and society from potential biosecurity, compliance and liability risks–all while keeping costs manageable.
How It Works
Our technology is based on threat identification algorithms built around Battelle’s proprietary sequence of concern database containing more than 10,000 curated sequences and peer-reviewed microbial pathogenesis information. Because the database is organized around specific sequences rather than matching against the full genomes of known pathogens, the algorithms can identify the specific sequence in question and provide reviewers with actionable information to easily understand the threat level of a sequence and context for how to handle any customer follow up.
|Virulence Factor Focused||Yes||No|
|Standardized and Objective Threat Status Score||Yes||No|
|Complex Pattern Identification||Yes||No|
|Comprehensive Reporting and Interpreting||Yes||No|
The database was built on more than a decade of research into the factors that make pathogens dangerous. It compiles more than 10,000 sequences of concern comprising 100% of bacterial human/zoonotic agents and > 70% of human/zoonotic agents.
- Virulence factor
- Antibiotic resistance
- Immune evasion factors
- Human bioregulators
- Protein toxins
- Other threat factors (e.g., opioid enzyme pathways)
Threat Identification Algorithm
The algorithm rapidly scans a requested DNA sequence and looks for matches within the threat factors database. Matches may be entire gene sequences or parts of gene sequences. Our algorithm also provides information about the types of threats that a gene sequence may present by analyzing the structures of the genes and their resulting functions.
Craig Bartling, Ph.D.Data ScientistCraig’s background is in biochemistry, but his scientific expertise spans many areas, such as genomics, proteomics and protein characterization, and molecular biology. He is a recognized leader in biological data curation, with particular emphasis in data pertaining to biological threats and genetic engineering.
Neeraj RaoBusiness Leader, Computational BiosecurityNeeraj has 20 years of experience in the biotechnology and healthcare industries. His career has spanned everything from co-founding a venture-backed tech startup to leading global business development efforts at publicly traded biotechnology companies.
Biosecurity and Pandemic Preparedness
- National Security
- Chemical and Biological Threats
- Emerging Threats
- Public Health
- Chemical Agent Countermeasures
- Data Science
- Analytical Chemistry
- Bioaerosol Science
- Biological Chemistry
- Biological Engineering
- Biomedical Engineering
- Cell and Molecular Biology
- Chemical Engineering
- Data Analytics
- Modeling and Simulation