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Battelle Life Sciences Research CRO+ Today

Battelle Life Sciences Research CRO+ Today

January 2016 - Issue 4

Characterization of a Nose-only Inhaled Phosgene Acute Lung Injury Mouse Model

Phosgene is used as a chemical intermediate in the production of pesticides, plastics, dyes, polyurethanes and pharmaceuticals. Nearly a million metric tons of phosgene are produced and used annually in the United States with a potential exposure of approximately 10,000 workers. Due to phosgene’s wide availability and use in both the chemical and pharmaceutical industries, it is a health concern from both accidental and deliberate releases.