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Battelle Life Sciences Research CRO+ Today

Battelle Life Sciences Research CRO+ Today

Characterizing Acute Oral Toxicity of Phorate Oxon (PHO)

Phorate is an extremely toxic broad-use insecticide and ascaricide, commonly applied as a granular agricultural product for long-term release and systemic uptake by plants to control specific pests, such as sucking insects on peanut and nematodes in soybean plants. Battelle researchers conducted a study to characterize the oral toxicity of phorate oxon (PHO), with an emphasis on gender- and age-related effects.

Agricultural use of phorate has been linked to adverse environmental consequences and identified as a potential public health concern. Phorate is rapidly metabolized by plants, insects and mammals into several organophosphorus (OP) anti-cholinesterase (anti-ChE) intermediates that are even more toxic than the parent compound. While animal toxicity data of the parent compound phorate has been reported, relatively little is known about its more toxic metabolites. Battelle researchers recently published the results of a study that 1) evaluated the oral/ingestion toxicity of PHO in the Sprague-Dawley rat and 2) investigated and characterized any potential differences in susceptibility due to gender and age.

The study was coauthored by Battelle researchers Michael Babin, Kevin G. McGarry and Thomas H. Snider, along with David A. Jett, Gennady E. Platoff Jr. and David T. Yeung of the National Institutes of Health (NIH).