Case Studies

Battelle sought to develop new flowable concentrate seed treatment (FS) formulations with fungicidal active ingredients, incorporating non-microplastic seed binders for a key client.

Battelle was selected to support both nonclinical and clinical programs to help determine the effectiveness of candidate countermeasures for Sudan and Marburg viruses.

The current lack of licensed countermeasures for alphaviruses is a challenge, necessitating the development of effective vaccines and therapeutics.

The high-profile Zika virus outbreak in 2016 proved that the disease causes serious birth defects in humans and highlighted a need for vaccines and treatments. Battelle was chosen to pursue development of assays, evaluate the immune response, and evaluate efficacy and immunogenicity of multiple Zika vaccine and therapeutic candidates.

The 2014 Ebola epidemic prompted an urgent need for an approved vaccine to treat or prevent the disease in future outbreaks. Based on Battelle’s extensive experience in vaccine testing and managing highly regulated, complex projects involving high-containment pathogens, we were chosen to evaluate the immunogenicity and efficacy of Ebola vaccine candidates to determine if they were protective.

Read on how Battelle was tasked with performing preclinical safety studies to determine cause of toxicity in preclinical models of a nerve agent antidote for the DOD.

A key client sought to conduct a radiovalidation study that required the extraction of radiolabelled pesticides from soil. The client requested to incorporate a specific piece of equipment into the pesticide extraction methodology that Battelle Crop Protection did not own. In addition, scientific research available on the use of this equipment was limited. What steps did Battelle Crop Protection take to address the challenge, overcome the limitations of existing techniques, and meet the clients’ requirements?

We're improving the quality of life for the 5.3 million Americans who suffer from an ABI with our innovative biofeedback device.

A medical device manufacturer released a medical instrument that combined glass and plastic components. The plastic component was made of polyether ether ketone (PEEK), which was joined to the glass component using a cured epoxy. Through Battelle’s Surface Science program we identified an atmospheric plasma treatment as an approach to solve the adhesion problem and avoid changes to the product design or manufacturing process

A pharmaceutical company was evaluating potential options for a combination drug and injection device for a highly viscous drug. The viscosity of the drug made it difficult to inject by hand. To improve safety and reduce hand fatigue, they needed to modify the flanges or thumb pad on the syringe. There were custom-made and commercial-off-the-shelf (COTS) options available. Our client came to Battelle for help in deciding which one modification option would be most likely to be accepted by their end users.

Learn how Battelle enabled the safe capture of 2+ million metric tons of CO2.

In recent years, the U.S. federal government has identified a need for lower-cost non-standard commercial vehicles (NSCV). NSCVs – such as pick-up trucks, sport-utility vehicles, sedans, and vans – allow military forces to operate in areas without military logistical support. For more than eight years, Battelle has produced lightweight armored and upgraded vehicles for clients who sought better operational performance and protection.

The University of Alaska and Battelle received an NSF award to bring together research and local people’s needs and determine what information/observations are needed to secure sustainable food supplies in near-coastal Arctic ecosystems.

Mycoremediation is a form of bioremediation that uses fungi to break down and extract contaminants from the environment. However, using live fungal cultures is problematic. Battelle developed an encapsulation technology to protect the enzymes from physical and chemical degradation.

Corrosion costs industry billions of dollars every year—more than $7 billion annually for oil and gas pipelines alone. We developed a smart microbead that breaks open when corrosion is detected. The smart beads look like a fine white powder and can be mixed into paints and coatings.

A sponsor organization developed a novel oncolytic viral therapeutic of genetically engineered herpes simplex virus type 1 (HSV-1) targeted to treat glioblastoma. Battelle was contracted to complete a GLP, IND-enabling study, evaluating the toxicity, biodistribution and efficacy of the therapeutic in a human orthotopic xenograft model.

Battelle worked with the U.S. Navy, the U.S. Army and the U.S. Army Corps of Engineers (USACE) to develop a stand-alone tool called SiteWise™ to evaluate and quantify the environmental, health, safety and economic impact of a variety of restoration alternatives. SiteWise™ expands on existing Life Cycle Assessment (LCA) concepts to conduct GSR assessments specifically tailored to site restoration and remediation.

Battelle's combined metagenomic and metaproteomic analytical approaches demonstrated how microorganisms respond to changes in the environment such as exposure to crude oil. The microbial response to crude oil was investigated using genetic sequence profiling (metagenomics) and functional protein profiling (metaproteomic) to observe perturbations in microbial biodiversity and functional protein content.

While many who travel in airports are rushing to catch a flight, we take for granted the technology that keeps us safe -- the baggage scanner. An airport security screener’s ability to find weapons or explosives hidden in luggage can be affected by the visual complexity of the X-ray image. The Transportation Security Administration (TSA) asked Battelle to create an objective, quantitative measure of visual complexity so that its effects on screening performance could be studied more rigorously.

A medical device manufacturer was experiencing an intermittent problem with an injection-molded plastic component. During startup, parts would come off the line with a small blister in the plastic. They came to Battelle for help in solving the mystery.