Service Solution

ThreatSEQ™ DNA Screening Web Service

Battelle’s innovation is changing the industry and shaping the future. Our rapid DNA screening software for sequences of concern gives synthetic biologists a powerful new resource for reducing risk. This technology dramatically reduces the possibility that dangerous organisms will be accidentally or deliberately created through gene synthesis.
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Faster, Better Decisions for the Gene Synthesis Industry  

ThreatSEQ DNA screening web service offers gene synthesis companies a faster alternative to manual and subjective DNA screening options. Now, these institutions are empowered to make better decisions for protecting themselves, their customers and society from potential biosecurity, compliance and liability risks–all while keeping costs manageable.  

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How It Works

Our technology is based on threat identification algorithms built around Battelle’s proprietary sequence of concern database containing more than 10,000 curated sequences and peer-reviewed microbial pathogenesis information. Because the database is organized around specific sequences rather than matching against the full genomes of known pathogens, the algorithms can identify the specific sequence in question and provide reviewers with actionable information to easily understand the threat level of a sequence and context for how to handle any customer follow up.   



Current Practice

Virulence Factor FocusedYesNo
Linked MetadataYesNo
Continuous UpdatingYesNo
Standardized and Objective Threat Status Score YesNo
Complex Pattern IdentificationYesNo
Comprehensive Reporting and InterpretingYesNo
High Accuracy YesNo
Focused Input YesNo

ThreatSEQ Database

The database was built on more than a decade of research into the factors that make pathogens dangerous. It compiles more than 10,000 sequences of concern comprising 100% of bacterial human/zoonotic agents and > 70% of human/zoonotic agents.


  • Virulence factor
  • Antibiotic resistance
  • Immune evasion factors
  • Human bioregulators
  • Protein toxins
  • Other threat factors (e.g., opioid enzyme pathways)
Photo: Battelle ThreatSEQ technology scanning DNA sequences

Threat Identification Algorithm  

The algorithm rapidly scans a requested DNA sequence and looks for matches within the threat factors database. Matches may be entire gene sequences or parts of gene sequences. Our algorithm also provides information about the types of threats that a gene sequence may present by analyzing the structures of the genes and their resulting functions.   

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